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Ant, and the Mayo Clinic Clinician Investigator Training Program (LGT). Author details 1 The Texas Brain and Spine Institute, 8441 St. Hwy 47, Suite 4300, Bryan, TX 77807, USA. 2Department of Neuroscience and Experimental Therapeutics, Texas A M HSC College of Medicine, 2006 MREB, 8447 St. Hwy 47, Bryan, TX 77807, USA. 3Department of Neurology, Mayo Clinic, Rochester, MN, USA. 4 Division of Biomed
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Gical importance of FLNA and suggest that targeting this protein might be useful in cancer therapeutics. Keywords: Cancer, Angiogenesis, Cytoskeleton, MigrationBackground Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes during cell movements [1]. Filamins crosslink cortical filamentous actin into a dynamic orthog
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Ed by the current ones, highlight a major role for galectin-1 in GBM invasiveness. The characteristic malignant phenotype of glioblastoma extends beyond aggressive invasion. This tumor develops resistance to chemo- and radio-therapy, it promotes neoangiogenesis, and it seems to benefit from immune privilege. Interestingly, galectin-1 may play a role in promoting each of these phenotypes. While gal
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Kara S, Karamycheva S, Pertea G, Sultana R, Antonescu V, Chan A, Cheung F, Quackenbush J: The TIGR Gene Indices: clustering and assembling EST and known genes and integration with eukaryotic genomes. Nucleic Acids Res 2005, 33:D71-4. TIGR Zebrafish Gene Index [http://www.tigr.org/tigr-scripts/tgi/ T_index.cgi?species=zfish] Hill AJ, Teraoka H, Heideman W, Peterson RE: Zebrafish as a model vertebra
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N expression differences. In addition to gel-based proteomics, the deyolking protocol also is crucial for gel free mass spectrometry-based proteomics. There are numerous applications for quantitative proteomics in zebrafish: analysis of specific zebrafish mutants as well as the analysis of gain and loss of functions induced by RNA or Morpholino injections will provide a better molecular understand
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Opathol Exp Neurol 2008, 67:456?69. Le Mercier M, Fortin S, Mathieu V, Roland I, Spiegl-Kreinecker S, Haibe-Kains B, Bontempi G, Decaestecker C, Berger W, Lefranc F, Kiss R: Galectin-1 proangiogenic and promigratory effects in the Hs683 oligodendroglioma25.26.27.28.29.30.31. 32.33.34.35.36.37.38.39.40.41.42. 43. 44.model are partly mediated through the control of BEX2 expression. Neoplasia 2009, 1
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Bryos In the early embryo, the cells forming the embryo proper constitute only a minor volume of the embryo compared to the large yolk cell (Fig. 1B). The abundance of yolk proteins interferes with any proteomic application that intends to target the cells of the embryo proper. The major yolk protein Vitellogenin, a phospholipo-glycoprotein,Page 1 of(page number not for citation purposes)BMC Devel
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S 1. Lefranc F, Facchini V, Kiss R: Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas. Oncologist 2007, 12:1395?403. 2. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E,

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